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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50304297
Substrate
n/a
Meas. Tech.
ChEMBL_606463 (CHEMBL1074028)
IC50
1.7±n/a nM
Citation
 Haga, Y; Sakamoto, T; Shibata, T; Nonoshita, K; Ishikawa, M; Suga, T; Takahashi, H; Takahashi, T; Takahashi, H; Ando, M; Murai, T; Gomori, A; Oda, Z; Kitazawa, H; Mitobe, Y; Kanesaka, M; Ohe, T; Iwaasa, H; Ishii, Y; Ishihara, A; Kanatani, A; Fukami, T Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist. Bioorg Med Chem 17:6971-82 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50435.58
Organism:
Rat 6B
Description:
NPY-Y5 NPY5R Rat 6B::Q63634
Residue:
445
Sequence:
MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM50304297
Synonyms:
CHEMBL594163 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-3-yl)-3H-spiro[4-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide
Type:
Small organic molecule
Emp. Form.:
C22H20N4O3
Mol. Mass.:
388.4192
SMILES:
O=C(Nc1ccn(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21 |r,wU:17.22,wD:14.15,(24.81,-8.6,;25.58,-9.94,;27.12,-9.94,;28,-11.21,;29.55,-11.24,;29.99,-12.71,;28.72,-13.59,;27.5,-12.65,;28.69,-15.12,;27.34,-15.86,;27.3,-17.4,;28.62,-18.2,;29.97,-17.45,;30,-15.91,;24.81,-11.27,;23.27,-11.27,;22.5,-12.6,;23.27,-13.93,;24.81,-13.93,;25.58,-12.6,;24.19,-15.19,;23.28,-16.44,;23.75,-17.91,;21.8,-15.96,;20.47,-16.74,;19.14,-15.96,;19.14,-14.42,;20.47,-13.65,;21.8,-14.41,)|
Structure:
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