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Found 434 with Last Name = 'suga' and Initial = 't'
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50019290(CHEMBL3289390)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50377964(Cantil | Glycophenylate | MEPENZOLATE BROMIDE | Me...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50019290(CHEMBL3289390)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]NMS from human M3R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50019289(CHEMBL3289391)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50377964(Cantil | Glycophenylate | MEPENZOLATE BROMIDE | Me...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]NMS from human M3R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50019289(CHEMBL3289391)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]NMS from human M3R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM23274((2E)-3-(2,4-dichlorophenyl)-N-hydroxyprop-2-enamid...)
Affinity DataKi:  300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A using SNAP-25 (141-206) as substrate by HPLC analysisMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM23274((2E)-3-(2,4-dichlorophenyl)-N-hydroxyprop-2-enamid...)
Affinity DataKi:  300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chainMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546871(CHEMBL4745069)
Affinity DataKi:  2.00E+3nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50048539(CHEMBL3309328)
Affinity DataKi:  7.70E+3nMAssay Description:Irreversible inhibition of recombinant Clostridium botulinum N-terminal 6His-tagged BoNT/A (Met1 to Phe425 residues) catalytic domain expressed in Es...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546870(CHEMBL4790141)
Affinity DataKi:  8.90E+3nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546872(CHEMBL4761825)
Affinity DataKi:  1.70E+4nMAssay Description:Time dependent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate by me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546874(CHEMBL4795025)
Affinity DataKi:  3.20E+4nMAssay Description:Time dependent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate by me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546876(CHEMBL4787837)
Affinity DataKi:  3.80E+4nMAssay Description:Time dependent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate by me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546880(CHEMBL4799810)
Affinity DataKi:  4.10E+4nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546875(CHEMBL4746123)
Affinity DataKi:  4.80E+4nMAssay Description:Time dependent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate by me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50048539(CHEMBL3309328)
Affinity DataKi:  5.20E+4nMAssay Description:Covalent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546878(CHEMBL4790780)
Affinity DataKi:  6.60E+4nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546877(CHEMBL4743480)
Affinity DataKi:  8.80E+4nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546879(CHEMBL4787587)
Affinity DataKi:  8.80E+4nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50546881(CHEMBL4761785)
Affinity DataKi:  9.98E+5nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258478(2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[fur...)
Affinity DataIC50:  0.0900nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258477(2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-1H-s...)
Affinity DataIC50:  0.150nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268532(3-oxo-N-(5-phenylpyrimidin-2-yl)-3H-spiro[isobenzo...)
Affinity DataIC50:  0.670nMAssay Description:Displacement of [125I]PYY from rat NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268739(CHEMBL524085 | N-(3-(4-chlorophenyl)isoxazol-5-yl)...)
Affinity DataIC50:  0.690nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268737(CHEMBL526084 | N-(3-(2-chlorophenyl)isoxazol-5-yl)...)
Affinity DataIC50:  0.830nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268700(3-oxo-N-(3-phenylisoxazol-5-yl)-3H-spiro[isobenzof...)
Affinity DataIC50:  0.840nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268651(3-oxo-N-(5-(3-(trifluoromethyl)phenyl)pyrimidin-2-...)
Affinity DataIC50:  0.850nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304315(CHEMBL593465 | trans-3-Oxo-N-(2-phenyl-2H-1,2,3-tr...)
Affinity DataIC50:  0.890nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268534(CHEMBL521545 | N-(5-(3-chlorophenyl)pyrimidin-2-yl...)
Affinity DataIC50:  0.910nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304301(CHEMBL595790 | trans-N-[1-(3-Fluorophenyl)-1H-pyra...)
Affinity DataIC50:  0.920nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268597(CHEMBL521537 | N-(5-(2-fluorophenyl)pyrimidin-2-yl...)
Affinity DataIC50:  0.990nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258315((+/-)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268738(CHEMBL497621 | N-(3-(3-chlorophenyl)isoxazol-5-yl)...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268533(CHEMBL496196 | N-(5-(2-chlorophenyl)pyrimidin-2-yl...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268594(CHEMBL523060 | N-(5-(2-methoxyphenyl)pyrimidin-2-y...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268648(CHEMBL495630 | N-(5-(3-fluorophenyl)pyrimidin-2-yl...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304313(CHEMBL607037 | trans-3-Oxo-N-(2-phenyl-1,3-thiazol...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268883(3-oxo-N-(5-phenyl-1,2,4-thiadiazol-3-yl)-3H-spiro[...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50265209(1'-(5-chloro-1H-benzo[d]imidazol-2-yl)-3H-spiro[is...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at human NPY Y5 receptor transfected in mouse LMtk cells assessed as inhibition of neuropeptide Y-induced increase in intercellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268650(3-oxo-N-(5-(2-(trifluoromethyl)phenyl)pyrimidin-2-...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268739(CHEMBL524085 | N-(3-(4-chlorophenyl)isoxazol-5-yl)...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]PYY from rat NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304300(CHEMBL595573 | trans-N-[1-(2-fluorophenyl)-3-pyraz...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304298(CHEMBL595120 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258450((+/-)-2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spi...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50258450((+/-)-2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spi...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50264726(1'-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-3H-spir...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at human NPY Y5 receptor transfected in mouse LMtk cells assessed as inhibition of neuropeptide Y-induced increase in intercellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50268532(3-oxo-N-(5-phenylpyrimidin-2-yl)-3H-spiro[isobenzo...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50265298(CHEMBL496327 | methyl 2-(3-oxo-3H-spiro[isobenzofu...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human NPY Y5 receptor transfected in mouse LMtk cells assessed as inhibition of neuropeptide Y-induced increase in intercellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50304303(CHEMBL593934 | trans-3-Oxo-N-(5-phenylpyrazin-2-yl...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [125I]PYY from human recombinant Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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