Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50268739
Substrate
n/a
Meas. Tech.
ChEMBL_523824 (CHEMBL1008336)
IC50
1.3±n/a nM
Citation
 Takahashi, T; Haga, Y; Sakamoto, T; Moriya, M; Okamoto, O; Nonoshita, K; Shibata, T; Suga, T; Takahashi, H; Hirohashi, T; Sakuraba, A; Gomori, A; Iwaasa, H; Ohe, T; Ishihara, A; Ishii, Y; Kanatani, A; Fukami, T Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists. Bioorg Med Chem Lett 19:3511-6 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50435.58
Organism:
Rat 6B
Description:
NPY-Y5 NPY5R Rat 6B::Q63634
Residue:
445
Sequence:
MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM50268739
Synonyms:
CHEMBL524085 | N-(3-(4-chlorophenyl)isoxazol-5-yl)-3-oxo-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-carboxamide
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O4
Mol. Mass.:
423.849
SMILES:
Clc1ccc(cc1)-c1cc(NC(=O)N2CCC3(CC2)OC(=O)c2ccccc32)on1
Structure:
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