Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50305989
Substrate
n/a
Meas. Tech.
ChEMBL_605682 (CHEMBL1071212)
Ki
0.39±n/a nM
Citation
 Gilbert, EJ; Zhou, G; Wong, MK; Tong, L; Shankar, BB; Huang, C; Kelly, J; Lavey, BJ; McCombie, SW; Chen, L; Rizvi, R; Dong, Y; Shu, Y; Kozlowski, JA; Shih, NY; Hipkin, RW; Gonsiorek, W; Malikzay, A; Lunn, CA; Favreau, L; Lundell, DJ Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors. Bioorg Med Chem Lett 20:608-11 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50305989
Synonyms:
CHEMBL596387 | N-((1-(4-chloro-2-(2-fluorophenylsulfonyl)phenylsulfonyl)-4-methylpiperidin-4-yl)methyl)-1,1,1-trifluoromethanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H21ClF4N2O6S3
Mol. Mass.:
593.032
SMILES:
CC1(CNS(=O)(=O)C(F)(F)F)CCN(CC1)S(=O)(=O)c1ccc(Cl)cc1S(=O)(=O)c1ccccc1F
Structure:
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