Reaction Details Report a problem with these data
Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50119362
Substrate
n/a
Meas. Tech.
ChEMBL_665404 (CHEMBL1261133)
IC50
13.3±n/a nM
Citation
Tang, H; Yan, Y; Feng, Z; de Jesus, RK; Yang, L; Levorse, DA; Owens, KA; Akiyama, TE; Bergeron, R; Castriota, GA; Doebber, TW; Ellsworth, KP; Lassman, ME; Li, C; Wu, MS; Zhang, BB; Chapman, KT; Mills, SG; Berger, JP; Pasternak, A Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett 20:6088-92 (2010) [PubMed] Article
More Info.:
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
Inhibitor
Name:
BDBM50119362
Synonyms:
2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-3-methyl-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol | CHEMBL102718
Type:
Small organic molecule
Emp. Form.:
C25H19F10NO4
Mol. Mass.:
587.4067
SMILES:
Cc1cc(ccc1C(Cc1cc[n+]([O-])cc1)c1ccc(OC(F)F)c(OC(F)F)c1)C(O)(C(F)(F)F)C(F)(F)F