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Target
72 kDa type IV collagenase
Ligand
BDBM50343066
Substrate
n/a
Meas. Tech.
ChEMBL_744869 (CHEMBL1772890)
IC50
6.6±n/a nM
Citation
 Fobian, YM; Freskos, JN; Barta, TE; Bedell, LJ; Heintz, R; Kassab, DJ; Kiefer, JR; Mischke, BV; Molyneaux, JM; Mullins, P; Munie, GE; Becker, DP MMP-13 selective alpha-sulfone hydroxamates: identification of selective P1' amides. Bioorg Med Chem Lett 21:2823-5 (2011) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50343066
Synonyms:
CHEMBL1770712 | N-hydroxy-4-(4-(4-(4-methoxyphenoxy)butoxy)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H29NO8S
Mol. Mass.:
479.543
SMILES:
COc1ccc(OCCCCOc2ccc(cc2)S(=O)(=O)C2(CCOCC2)C(=O)NO)cc1
Structure:
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