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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50344576
Substrate
n/a
Meas. Tech.
ChEMBL_748173 (CHEMBL1781852)
IC50
6000±n/a nM
Citation
 Hebeisen, P; Haap, W; Kuhn, B; Mohr, P; Wessel, HP; Zutter, U; Kirchner, S; Ruf, A; Benz, J; Joseph, C; Alvarez-Sánchez, R; Gubler, M; Schott, B; Benardeau, A; Tozzo, E; Kitas, E Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase. Bioorg Med Chem Lett 21:3237-42 (2011) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_MOUSE | Fbp | Fbp1 | Fbp3
Type:
PROTEIN
Mol. Mass.:
36912.07
Organism:
Mus musculus
Description:
ChEMBL_748173
Residue:
338
Sequence:
MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK
  
Inhibitor
Name:
BDBM50344576
Synonyms:
CHEMBL1778453 | N-(6-amino-4-(trifluoromethyl)pyridin-2-ylcarbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C15H17F3N4O4S2
Mol. Mass.:
438.445
SMILES:
COCCc1sc(cc1C)S(=O)(=O)NC(=O)Nc1cc(cc(N)n1)C(F)(F)F
Structure:
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