Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50348679
Substrate
n/a
Meas. Tech.
ChEMBL_754458 (CHEMBL1806083)
IC50
2000±n/a nM
Citation
Becker, DP; Barta, TE; Bedell, LJ; Boehm, TL; Bond, BR; Carroll, J; Carron, CP; Decrescenzo, GA; Easton, AM; Freskos, JN; Funckes-Shippy, CL; Heron, M; Hockerman, S; Howard, CP; Kiefer, JR; Li, MH; Mathis, KJ; McDonald, JJ; Mehta, PP; Munie, GE; Sunyer, T; Swearingen, CA; Villamil, CI; Welsch, D; Williams, JM; Yu, Y; Yao, J Orally active MMP-1 sparinga-tetrahydropyranyl anda-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem 53:6653-80 (2010) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN