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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50359497
Substrate
n/a
Meas. Tech.
ChEMBL_792733 (CHEMBL1930560)
IC50
>10000±n/a nM
Citation
 Chen, X; Zhang, S; Yang, Y; Hussain, S; He, M; Gui, D; Ma, B; Jing, C; Qiao, Z; Zhu, C; Yu, Q 1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase. Bioorg Med Chem 19:7262-9 (2011) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50359497
Synonyms:
CHEMBL1927020
Type:
Small organic molecule
Emp. Form.:
C17H14F3NO4S
Mol. Mass.:
385.358
SMILES:
OC(=O)CC1CN(Cc2cc(F)c(F)cc2F)S(=O)(=O)c2ccccc12
Structure:
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