Target
Thromboxane-A synthase
Ligand
BDBM50028712
Substrate
n/a
Meas. Tech.
ChEBML_210443
IC50
56±n/a nM
Citation
 Iizuka, KAkahane, KMomose, DNakazawa, MTanouchi, TKawamura, MOhyama, IKajiwara, IIguchi, YOkada, TTaniguchi, KMiyamoto, THayashi, M Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives. J Med Chem 24:1139-48 (1982) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50028712
Synonyms:
8-Imidazol-1-yl-oct-6-enoic acid; hydrochloride | CHEMBL542301
Type:
Small organic molecule
Emp. Form.:
C11H16N2O2
Mol. Mass.:
208.2569
SMILES:
OC(=O)CCCC\C=C/Cn1ccnc1
Structure:
Search PDB for entries with ligand similarity: