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Target
RNA-directed RNA polymerase
Ligand
BDBM50199059
Substrate
n/a
Meas. Tech.
ChEMBL_411597 (CHEMBL907248)
IC50
120±n/a nM
Citation
 Ikegashira, K; Oka, T; Hirashima, S; Noji, S; Yamanaka, H; Hara, Y; Adachi, T; Tsuruha, J; Doi, S; Hase, Y; Noguchi, T; Ando, I; Ogura, N; Ikeda, S; Hashimoto, H Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors. J Med Chem 49:6950-3 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50199059
Synonyms:
2-(4-(benzyloxy)phenyl)-3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid | CHEMBL217213
Type:
Small organic molecule
Emp. Form.:
C29H29NO3
Mol. Mass.:
439.5455
SMILES:
Cn1c(c(C2CCCCC2)c2ccc(cc12)C(O)=O)-c1ccc(OCc2ccccc2)cc1
Structure:
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