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Target
Cystathionine beta-lyase MetC
Ligand
BDBM50370869
Substrate
n/a
Meas. Tech.
ChEMBL_425863 (CHEMBL856866)
IC50
530±n/a nM
Citation
 Ejim, LJ; Blanchard, JE; Koteva, KP; Sumerfield, R; Elowe, NH; Chechetto, JD; Brown, ED; Junop, MS; Wright, GD Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. J Med Chem 50:755-64 (2007) [PubMed]  Article 
Target
Name:
Cystathionine beta-lyase MetC
Synonyms:
Beta-cystathionase | CBL | Cysteine lyase | METC_ECOLI | metC
Type:
PROTEIN
Mol. Mass.:
43211.38
Organism:
Escherichia coli K-12
Description:
ChEMBL_425863
Residue:
395
Sequence:
MADKKLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFDSVEAKKHATRNRANGELFYGRRGTLTHFSLQQAMCELEGGAGCVLFPCGAAAVANSILAFIEQGDHVLMTNTAYEPSQDFCSKILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVHDVPAIVAAVRSVVPDAIIMIDNTWAAGVLFKALDFGIDVSIQAATKYLVGHSDAMIGTAVCNARCWEQLRENAYLMGQMVDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALPGSKGHEFWKRDFTGSSGLFSFVLKKKLNNEELANYLDNFSLFSMAYSWGGYESLILANQPEHIAAIRPQGEIDFSGTLIRLHIGLEDVDDLIADLDAGFARIV
  
Inhibitor
Name:
BDBM50370869
Synonyms:
CHEMBL220764
Type:
Small organic molecule
Emp. Form.:
C21H12BrN3O7
Mol. Mass.:
498.24
SMILES:
[O-][N+](=O)c1ccc2c(c1)[c-](N=[OH+])c1cc(cc(C(=O)OCc3ccccc3Br)c21)[N+]([O-])=O
Structure:
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