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Target
Xaa-Pro aminopeptidase 1
Ligand
BDBM50151819
Substrate
n/a
Meas. Tech.
ChEMBL_461054 (CHEMBL944086)
IC50
>10000±n/a nM
Citation
 Kim, D; Kowalchick, JE; Brockunier, LL; Parmee, ER; Eiermann, GJ; Fisher, MH; He, H; Leiting, B; Lyons, K; Scapin, G; Patel, SB; Petrov, A; Pryor, KD; Roy, RS; Wu, JK; Zhang, X; Wyvratt, MJ; Zhang, BB; Zhu, L; Thornberry, NA; Weber, AE Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem 51:589-602 (2008) [PubMed]  Article 
Target
Name:
Xaa-Pro aminopeptidase 1
Synonyms:
Aminoacylproline aminopeptidase | Cytosolic aminopeptidase P | Soluble aminopeptidase P | X-Pro aminopeptidase 1 | X-prolyl aminopeptidase 1, soluble | XPNPEP1 | XPNPEPL | XPNPEPL1 | XPP1_HUMAN | sAmp
Type:
PROTEIN
Mol. Mass.:
69905.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_461054
Residue:
623
Sequence:
MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGRQEALEWLIRETQPISKQH
  
Inhibitor
Name:
BDBM50151819
Synonyms:
(R)-3-Amino-4-(2-fluoro-phenyl)-1-piperazin-1-yl-butan-1-one | (R)-3-amino-4-(2-fluorophenyl)-1-(piperazin-1-yl)butan-1-one | CHEMBL184624
Type:
Small organic molecule
Emp. Form.:
C14H20FN3O
Mol. Mass.:
265.3265
SMILES:
N[C@@H](CC(=O)N1CCNCC1)Cc1ccccc1F
Structure:
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