Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50375931
Substrate
n/a
Meas. Tech.
ChEMBL_474639 (CHEMBL921838)
IC50
110±n/a nM
Citation
 Na, YH; Hong, SH; Lee, JH; Park, WK; Baek, DJ; Koh, HY; Cho, YS; Choo, H; Pae, AN Novel quinazolinone derivatives as 5-HT7 receptor ligands. Bioorg Med Chem 16:2570-8 (2008) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50375931
Synonyms:
CHEMBL260514
Type:
Small organic molecule
Emp. Form.:
C32H36FN5O4
Mol. Mass.:
573.6577
SMILES:
CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1 |(15.25,-15.8,;15.95,-15.37,;16.68,-15.76,;17.38,-15.33,;18.1,-15.72,;18.81,-15.29,;18.78,-14.46,;18.06,-14.07,;17.36,-14.51,;16.63,-14.12,;15.93,-14.54,;15.21,-14.16,;15.18,-13.33,;14.47,-12.92,;13.75,-13.33,;13.04,-12.92,;12.33,-13.34,;12.33,-14.16,;11.61,-12.93,;10.9,-13.34,;10.18,-12.93,;9.46,-13.35,;8.74,-12.94,;8.02,-13.35,;7.31,-12.94,;6.6,-13.35,;7.31,-12.11,;8.02,-11.7,;8.74,-12.1,;9.45,-11.68,;9.45,-10.86,;10.18,-12.1,;10.89,-11.68,;11.61,-12.1,;12.32,-11.68,;12.32,-10.86,;11.6,-10.45,;10.89,-10.86,;10.17,-10.45,;10.16,-9.63,;15.88,-12.9,;16.61,-13.29,)|
Structure:
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