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Target
Mitogen-activated protein kinase 8
Ligand
BDBM50376122
Substrate
n/a
Meas. Tech.
ChEMBL_475208 (CHEMBL921936)
IC50
1050±n/a nM
Citation
 Asano, Y; Kitamura, S; Ohra, T; Itoh, F; Kajino, M; Tamura, T; Kaneko, M; Ikeda, S; Igata, H; Kawamoto, T; Sogabe, S; Matsumoto, S; Tanaka, T; Yamaguchi, M; Kimura, H; Fukumoto, S Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2). Bioorg Med Chem 16:4699-714 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 8
Synonyms:
Jnk1 | MK08_RAT | Mapk8 | Prkm8
Type:
PROTEIN
Mol. Mass.:
46809.57
Organism:
Rattus norvegicus
Description:
ChEMBL_475208
Residue:
411
Sequence:
MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD
  
Inhibitor
Name:
BDBM50376122
Synonyms:
CHEMBL260065
Type:
Small organic molecule
Emp. Form.:
C25H23ClN4O5S
Mol. Mass.:
526.992
SMILES:
CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(n(CC(N)=O)n1)S(C)(=O)=O
Structure:
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