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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50377724
Substrate
n/a
Meas. Tech.
ChEMBL_479969 (CHEMBL932362)
IC50
1.9±n/a nM
Citation
 Aster, SD; Graham, DW; Kharbanda, D; Patel, G; Ponpipom, M; Santorelli, GM; Szymonifka, MJ; Mundt, SS; Shah, K; Springer, MS; Thieringer, R; Hermanowski-Vosatka, A; Wright, SD; Xiao, J; Zokian, H; Balkovec, JM Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett 18:2799-804 (2008) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50377724
Synonyms:
CHEMBL401883
Type:
Small organic molecule
Emp. Form.:
C21H18ClN3O3S
Mol. Mass.:
427.904
SMILES:
COc1c(ccc2ccc(Cl)cc12)-c1nnc(-c2ccccc2S(C)(=O)=O)n1C
Structure:
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