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Target
B-cell receptor CD22
Ligand
BDBM50378465
Substrate
n/a
Meas. Tech.
ChEMBL_599602 (CHEMBL1040214)
IC50
305200±n/a nM
Citation
 Abdu-Allah, HH; Watanabe, K; Hayashizaki, K; Takaku, C; Tamanaka, T; Takematsu, H; Kozutsumi, Y; Tsubata, T; Ishida, H; Kiso, M Potent small molecule mouse CD22-inhibitors: exploring the interaction of the residue at C-2 of sialic acid scaffold. Bioorg Med Chem Lett 19:5573-5 (2009) [PubMed]  Article 
Target
Name:
B-cell receptor CD22
Synonyms:
B-lymphocyte cell adhesion molecule | BL-CAM | CD22_MOUSE | CD_antigen=CD22 | Cd22 | Lyb-8 | Sialic acid-binding Ig-like lectin 2 | Siglec-2 | Siglec2 | T-cell surface antigen Leu-14
Type:
PROTEIN
Mol. Mass.:
96597.27
Organism:
Mus musculus
Description:
ChEMBL_727025
Residue:
862
Sequence:
MRVHYLWLLLILGHAASAQYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNILLFQNYEFDKATKKFKGTVLYNKAEPELYPPKQRRVTFLGNSIDNCTLKIHPIRANDSGNLGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFEYDILLQWFLEDSKITSVTPSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSEVLSERTVRLDVKYTPKLEIKVNPTEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSVTKDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYTWYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSFTPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVSCAACNHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLRLEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWGMKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAILRFPESDMHNAGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSELVQFGAGKRPQAKEDVDYVTLKH
  
Inhibitor
Name:
BDBM50378465
Synonyms:
CHEMBL569217
Type:
Small organic molecule
Emp. Form.:
C24H35NO16
Mol. Mass.:
593.5318
SMILES:
COc1ccc(O[C@@H]2O[C@H](CO[C@@]3(C[C@H](O)[C@H](NC(=O)CO)[C@@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)[C@H](O)[C@H](O)[C@H]2O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: