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Target
Myelin-associated glycoprotein
Ligand
BDBM50378606
Substrate
n/a
Meas. Tech.
ChEMBL_611876 (CHEMBL1070831)
Kd
17000±n/a nM
Citation
 Mesch, S; Moser, D; Strasser, DS; Kelm, A; Cutting, B; Rossato, G; Vedani, A; Koliwer-Brandl, H; Wittwer, M; Rabbani, S; Schwardt, O; Kelm, S; Ernst, B Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation. J Med Chem 53:1597-615 (2010) [PubMed]  Article 
Target
Name:
Myelin-associated glycoprotein
Synonyms:
MAG_MOUSE | Mag | Siglec-4a
Type:
PROTEIN
Mol. Mass.:
69368.91
Organism:
Mus musculus
Description:
ChEMBL_663794
Residue:
627
Sequence:
MIFLATLPLFWIMISASRGGHWGAWMPSTISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTIRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESSSFSGGDNPHVLYSPEFRISGAPDKYESEKQRLGSERRLLGLRGESPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
  
Inhibitor
Name:
BDBM50378606
Synonyms:
CHEMBL601720
Type:
Small organic molecule
Emp. Form.:
C24H26ClF2N2O10S
Mol. Mass.:
607.986
SMILES:
CS(=O)(=O)N[C@H]1[C@H](O)C[C@@](OCc2cccc(F)c2F)(O[C@H]1[C@H](O)[C@H](O)CNC(=O)c1ccc(Cl)cc1)C([O-])=O |r,@@:1|
Structure:
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