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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50385084
Substrate
n/a
Meas. Tech.
ChEMBL_821479 (CHEMBL2038009)
IC50
162±n/a nM
Citation
 Tsuhako, AL; Brown, DS; Koltun, ES; Aay, N; Arcalas, A; Chan, V; Du, H; Engst, S; Franzini, M; Galan, A; Huang, P; Johnston, S; Kane, B; Kim, MH; Laird, AD; Lin, R; Mock, L; Ngan, I; Pack, M; Stott, G; Stout, TJ; Yu, P; Zaharia, C; Zhang, W; Zhou, P; Nuss, JM; Kearney, PC; Xu, W The design, synthesis, and biological evaluation of PIM kinase inhibitors. Bioorg Med Chem Lett 22:3732-8 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50385084
Synonyms:
CHEMBL2035636
Type:
Small organic molecule
Emp. Form.:
C18H19BrN4O2
Mol. Mass.:
403.273
SMILES:
CN1C[C@@H]2CC[C@H]1CN2Cc1nc2c3cc(Br)ccc3oc2c(=O)[nH]1 |r|
Structure:
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