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Target
Phosphodiesterase
Ligand
BDBM50397078
Substrate
n/a
Meas. Tech.
ChEMBL_863633 (CHEMBL2175365)
IC50
130±n/a nM
Citation
Orrling, KM; Jansen, C; Vu, XL; Balmer, V; Bregy, P; Shanmugham, A; England, P; Bailey, D; Cos, P; Maes, L; Adams, E; van den Bogaart, E; Chatelain, E; Ioset, JR; van de Stolpe, A; Zorg, S; Veerman, J; Seebeck, T; Sterk, GJ; de Esch, IJ; Leurs, R Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1. J Med Chem 55:8745-56 (2012) [PubMed] Article
More Info.:
Target
Name:
Phosphodiesterase
Synonyms:
Class I phosphodiesterase PDEB1 | PDEB1
Type:
PROTEIN
Mol. Mass.:
103788.82
Organism:
Leishmania major
Description:
ChEMBL_863633
Residue:
940
Sequence:
MHSAVFSPDAPYCGAAGSNHLCEAVALCQSILARYRRTGTSFSSTELKAIQALRTEFPDTAQEPAANSAASPDQTTKDFLSILDDATDVPHNPQNDIVAFVEECCDNTKEPTVLFAAINERISAVTCSRNVRTYMVIANDNLLWDPVNGVAALIDDVTPLGKCAQARNMLTIANTLYIPLWFRSELVGCVEVPGACIPRDKATCAQLLLRCVTVAVRNSINISIRKREANKIEAMVGMATRLARDTLEESVLVQSIINTAKTLTESDRCSIFLVKADGSLEAHFEDGNVVVLPAGTGIAGHVAESGAVVNIPNAYEDDRFHRSVDKVTGYHTRTILCLPIAFEGTIVAVAQLINKLDMVTQSGQRLPRVFGRRDEELFETFSMFAAASLRNCRINETLLKEKKKSDAILDVVALLSNTDIRDVDSIVRHVLHGAKKLLNADRSSMFLLDKERNELYSKMADSANEIRFPCGQGIAGTVAESGVGENIMDAYADSRFNSAVDRQLGYRTQSILCEPITLNGEVLAVVQLVNKLGDDGSVTCFTPMDRETFQVFSLFAGISINNSHLLEFAVNAGREAMTLSLQRNSITAQRAPKSVKVIAVTPEEREAVMSIDFGGAYDFTSPGFNLFEVREKYSEPMDAAAGVVYNLLWNSGLPEKFGCREQTLLNFILQCRRRYRRVPYHNFYHVVDVCQTLHTYLYTGKASELLTELECYVLLVTALVHDLDHMGVNNSFYLKTDSPLGILSSASGNNSVLEVHHCSLAIEILSDPAADVFEGLSGQDVAYAYRALIDCVLATDMAKHADALSRFTELATSGFEKDNDTHRRLVMETLIKAGDVSNVTKPFETSRMWAMAVTEEFYRQGDMEKEKGVEVLPMFDRSKNNELARGQIGFIDFVAGKFFRDIVGNLFHGMQWCVDTVNSNRAKWQEILDGRRDSIRSSIV