Reaction Details Report a problem with these data
Target
Bombesin receptor subtype-3
Ligand
BDBM50400253
Substrate
n/a
Meas. Tech.
ChEMBL_872481 (CHEMBL2182521)
IC50
3.2±n/a nM
Citation
 Liu, P; Lanza, TJ; Chioda, M; Jones, C; Chobanian, HR; Guo, Y; Chang, L; Kelly, TM; Kan, Y; Palyha, O; Guan, XM; Marsh, DJ; Metzger, JM; Ramsay, K; Wang, SP; Strack, AM; Miller, R; Pang, J; Lyons, K; Dragovic, J; Ning, JG; Schafer, WA; Welch, CJ; Gong, X; Gao, YD; Hornak, V; Ball, RG; Tsou, N; Reitman, ML; Wyvratt, MJ; Nargund, RP; Lin, LS Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality. ACS Med Chem Lett 2:933-937 (2011) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50400253
Synonyms:
CHEMBL2179912
Type:
Small organic molecule
Emp. Form.:
C23H21ClF3N3O2S
Mol. Mass.:
495.945
SMILES:
CC(C)(C)c1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2cccc(Cl)c12)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: