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Target
NF-kappa-B inhibitor alpha
Ligand
BDBM50437349
Substrate
n/a
Meas. Tech.
ChEMBL_972404 (CHEMBL2412579)
IC50
30100±n/a nM
Citation
 Ozawa, M; Morita, M; Hirai, G; Tamura, S; Kawai, M; Tsuchiya, A; Oonuma, K; Maruoka, K; Sodeoka, M Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-kB Activation ACS Med Chem Lett 4:730-5 (2013) [PubMed]  Article 
Target
Name:
NF-kappa-B inhibitor alpha
Synonyms:
I-kappa-B-alpha | IKBA | IKBA_HUMAN | MAD3 | NF-kappa-B inhibitor alpha | NFKBI | NFKBIA
Type:
GST fusion protein
Mol. Mass.:
35584.84
Organism:
Homo sapiens (Human)
Description:
It was produced in E. coli as GST-tagged fusion protein (Santa Cruz Biotechnology).
Residue:
317
Sequence:
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL
  
Inhibitor
Name:
BDBM50437349
Synonyms:
25-HYDROXY PHYSALIN F
Type:
Small organic molecule
Emp. Form.:
C28H30O11
Mol. Mass.:
542.5312
SMILES:
C[C@@]12OC(=O)[C@@]3(O)CC[C@H]4[C@@H](C[C@H]5O[C@]55CC=CC(=O)[C@]45C)[C@@]45O[C@@]13[C@@H](C4=O)[C@]1(C)C[C@H]2OC(=O)[C@]1(O)CO5 |r,c:17,TLB:30:28:26:24.23,33:35:26:24.23,THB:36:35:26:24.23,29:28:26:24.23|
Structure:
Search PDB for entries with ligand similarity: