Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50437750
Substrate
n/a
Meas. Tech.
ChEMBL_973380 (CHEMBL2410086)
IC50
>10000±n/a nM
Citation
 Kwak, HJ; Pyun, YM; Kim, JY; Pagire, HS; Kim, KY; Kim, KR; Rhee, SD; Jung, WH; Song, JS; Bae, MA; Lee, DH; Ahn, JH Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents. Bioorg Med Chem Lett 23:4713-8 (2013) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50437750
Synonyms:
CHEMBL2409666
Type:
Small organic molecule
Emp. Form.:
C28H28N4O2S
Mol. Mass.:
484.613
SMILES:
OC(=O)CC1CCC(CC1)c1ccc(cc1)-c1nc2ccc(NC(=S)Nc3ccccc3)cc2[nH]1 |(80.86,-2.17,;79.32,-2.18,;78.54,-.86,;78.56,-3.52,;77.02,-3.54,;76.26,-4.88,;74.73,-4.89,;73.94,-3.56,;74.69,-2.22,;76.24,-2.21,;72.41,-3.59,;71.65,-4.93,;70.11,-4.95,;69.33,-3.62,;70.08,-2.28,;71.62,-2.26,;67.79,-3.64,;66.9,-4.89,;65.43,-4.43,;64.1,-5.22,;62.76,-4.45,;62.76,-2.91,;61.43,-2.15,;60.1,-2.92,;60.1,-4.46,;58.76,-2.16,;57.43,-2.93,;56.09,-2.17,;54.76,-2.94,;54.76,-4.48,;56.1,-5.26,;57.43,-4.48,;64.08,-2.13,;65.42,-2.89,;66.88,-2.41,)|
Structure:
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