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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50437755
Substrate
n/a
Meas. Tech.
ChEMBL_973379 (CHEMBL2410085)
IC50
277±n/a nM
Citation
 Kwak, HJ; Pyun, YM; Kim, JY; Pagire, HS; Kim, KY; Kim, KR; Rhee, SD; Jung, WH; Song, JS; Bae, MA; Lee, DH; Ahn, JH Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents. Bioorg Med Chem Lett 23:4713-8 (2013) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Enzyme
Mol. Mass.:
56810.61
Organism:
Mus musculus (mouse)
Description:
In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system.
Residue:
498
Sequence:
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVRDAAVSPDLGAGGDAPAPAPAPAHTRDKDGRTSVGDGYWDLRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCVIIASNIFVVAAFQIEKRLAVGALTEQMGLLLHVVNLATIICFPAAVALLVESITPVGSVFALASYSIMFLKLYSYRDVNLWCRQRRVKAKAVSTGKKVSGAAAQQAVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWFFHSCLNAVAELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRHGSSKWVARTGVFLTSAFFHEYLVSVPLRMFRLWAFTAMMAQVPLAWIVGRFFQGNYGNAAVWVTLIIGQPVAVLMYVHDYYVLNYDAPVGV
  
Inhibitor
Name:
BDBM50437755
Synonyms:
CHEMBL2409568
Type:
Small organic molecule
Emp. Form.:
C32H26ClF3N4O4
Mol. Mass.:
623.021
SMILES:
OC(=O)CC1CCC(CC1)c1ccc(cc1)-c1nc2ccc(NC(=O)c3nc(oc3C(F)(F)F)-c3ccccc3Cl)cc2[nH]1 |(85.43,-36.9,;83.89,-36.91,;83.11,-35.59,;83.13,-38.26,;81.59,-38.27,;80.83,-39.61,;79.29,-39.62,;78.51,-38.3,;79.26,-36.95,;80.8,-36.94,;76.97,-38.32,;76.21,-39.66,;74.67,-39.68,;73.89,-38.35,;74.64,-37.01,;76.18,-36.99,;72.35,-38.37,;71.46,-39.63,;69.99,-39.17,;68.65,-39.95,;67.32,-39.18,;67.32,-37.64,;65.98,-36.88,;64.65,-37.65,;64.65,-39.2,;63.31,-36.89,;61.91,-37.53,;60.87,-36.39,;61.63,-35.05,;63.14,-35.36,;64.29,-34.33,;65.75,-34.8,;63.96,-32.82,;65.37,-33.23,;59.34,-36.56,;58.44,-35.32,;56.91,-35.49,;56.29,-36.9,;57.21,-38.14,;58.73,-37.97,;59.65,-39.2,;68.64,-36.86,;69.98,-37.62,;71.44,-37.14,)|
Structure:
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