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Target
5'-nucleotidase
Ligand
BDBM50443532
Substrate
n/a
Meas. Tech.
ChEMBL_1275399 (CHEMBL3090248)
IC50
10400±n/a nM
Citation
 Iqbal, J; Saeed, A; Raza, R; Matin, A; Hameed, A; Furtmann, N; Lecka, J; Sévigny, J; Bajorath, J Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors. Eur J Med Chem 70:685-91 (2013) [PubMed]  Article 
Target
Name:
5'-nucleotidase
Synonyms:
5'-nucleotidase | 5NTD_RAT | Ecto-5'-nucleotidase (e5'NT) | Ecto-5-nucleotidase (e5'NT) | NT | Nt5 | Nt5e | Nte
Type:
Enzyme
Mol. Mass.:
63971.44
Organism:
Rattus norvegicus (Rat)
Description:
P21588
Residue:
576
Sequence:
MRPAAATAPKWLLLALSALLPLWPTAKSWELTIMHTNDVHSRLEQTSDDSTKCLNASLCVGGVARLFTKVQQIRKEEPNVLLLDAGDQYQGTIWFTVYKGLEVAHFMNLLGYDAMALGNHEFDNGVEGLIDPLLRNVKFPILSANIKARGPLAPQISGLYLPYKVLSVGGEVVGIVGYTSKETPFLSNPGTNLVFEDEVTALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHTNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKVEFDDKGNVVTSYGNPILLNSTIREDAAIKADINQWRIKLDNYSTQELGRTIVYLNGSAQECRFRECNMGNLICDAMINNNLRHPDEMFWNHVSMCIVNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDISRKPWDRVVQLKVLCTKCRVPIYEPLEMDKVYKVVLPSYLVNGGDGFQMIKDELLKHDSGDQDISVVSEYISKMKVIYPAVEGRIKFSAASHYQGSFPLIILSFWAVILVLYQ
  
Inhibitor
Name:
BDBM50443532
Synonyms:
CHEMBL3087995
Type:
Small organic molecule
Emp. Form.:
C10H9NO4S
Mol. Mass.:
239.248
SMILES:
Nc1ccc2cc(cc(O)c2c1)S(O)(=O)=O
Structure:
Search PDB for entries with ligand similarity: