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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50447455
Substrate
n/a
Meas. Tech.
ChEMBL_1288275 (CHEMBL3117558)
IC50
>100000±n/a nM
Citation
 Ardecky, RJ; Bobkova, EV; Kiffer-Moreira, T; Brown, B; Ganji, S; Zou, J; Pass, I; Narisawa, S; Iano, FG; Rosenstein, C; Cheltsov, A; Rascon, J; Hedrick, M; Gasior, C; Forster, A; Shi, S; Dahl, R; Vasile, S; Su, Y; Sergienko, E; Chung, TD; Kaunitz, J; Hoylaerts, MF; Pinkerton, AB; Millán, JL Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett 24:1000-4 (2014) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM50447455
Synonyms:
CHEMBL3114959
Type:
Small organic molecule
Emp. Form.:
C16H12N4O5S
Mol. Mass.:
372.355
SMILES:
O=C(CNS(=O)(=O)c1ccc2[nH]c(=O)oc2c1)Nc1cccc(c1)C#N
Structure:
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