Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 1
Ligand
BDBM50448483
Substrate
n/a
Meas. Tech.
ChEMBL_1294380 (CHEMBL3129165)
IC50
>1000000±n/a nM
Citation
 Valente, S; Liu, Y; Schnekenburger, M; Zwergel, C; Cosconati, S; Gros, C; Tardugno, M; Labella, D; Florean, C; Minden, S; Hashimoto, H; Chang, Y; Zhang, X; Kirsch, G; Novellino, E; Arimondo, PB; Miele, E; Ferretti, E; Gulino, A; Diederich, M; Cheng, X; Mai, A Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells. J Med Chem 57:701-13 (2014) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
ANM1_RAT | Histone-arginine N-methyltransferase PRMT1 | Hrmt1l2 | Prmt1
Type:
PROTEIN
Mol. Mass.:
40514.94
Organism:
Rattus norvegicus
Description:
ChEMBL_103589
Residue:
353
Sequence:
MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50448483
Synonyms:
CHEMBL3126647
Type:
Small organic molecule
Emp. Form.:
C27H23N7O
Mol. Mass.:
461.5178
SMILES:
Cc1cc(Nc2ccccc2NC(=O)c2cccc(Nc3ccnc4ccccc34)c2)nc(N)n1
Structure:
Search PDB for entries with ligand similarity: