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Target
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Ligand
BDBM50395399
Substrate
n/a
Meas. Tech.
ChEMBL_1454251 (CHEMBL3363801)
IC50
>100000±n/a nM
Citation
 Reck, F; Ehmann, DE; Dougherty, TJ; Newman, JV; Hopkins, S; Stone, G; Agrawal, N; Ciaccio, P; McNulty, J; Barthlow, H; O'Donnell, J; Goteti, K; Breen, J; Comita-Prevoir, J; Cornebise, M; Cronin, M; Eyermann, CJ; Geng, B; Carr, GR; Pandarinathan, L; Tang, X; Cottone, A; Zhao, L; Bezdenejnih-Snyder, N Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa. Bioorg Med Chem 22:5392-409 (2014) [PubMed]  Article 
Target
Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Synonyms:
HCN4 | HCN4_HUMAN
Type:
PROTEIN
Mol. Mass.:
129069.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454251
Residue:
1203
Sequence:
MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLPSNL
  
Inhibitor
Name:
BDBM50395399
Synonyms:
CHEMBL2165063
Type:
Small organic molecule
Emp. Form.:
C24H28N6O4
Mol. Mass.:
464.5169
SMILES:
COc1ccc2ncc(=O)n(CCN3CCC(CC3)NCc3ccc4OCC(=O)Nc4n3)c2c1
Structure:
Search PDB for entries with ligand similarity: