Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 5B
Ligand
BDBM50033888
Substrate
n/a
Meas. Tech.
ChEMBL_1436463 (CHEMBL3390778)
Ki
11500±n/a nM
Citation
 Cumaraswamy, AA; Lewis, AM; Geletu, M; Todic, A; Diaz, DB; Cheng, XR; Brown, CE; Laister, RC; Muench, D; Kerman, K; Grimes, HL; Minden, MD; Gunning, PT Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein. ACS Med Chem Lett 5:1202-1206 (2014) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 5B
Synonyms:
STA5B_HUMAN | STAT5B | Signal transducer and activator of transcription 5B | Transcription factor STAT5b (STAT5b)
Type:
Protein
Mol. Mass.:
89858.26
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
787
Sequence:
MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
  
Inhibitor
Name:
BDBM50033888
Synonyms:
CHEMBL3358610
Type:
Small organic molecule
Emp. Form.:
C31H33F5N2O6S
Mol. Mass.:
656.661
SMILES:
CN(CC(=O)N(Cc1cc(cc(c1)C(C)(C)C)C(C)(C)C)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Structure:
Search PDB for entries with ligand similarity: