Reaction Details Report a problem with these data
Target
Diacylglycerol lipase-alpha
Ligand
BDBM50048620
Substrate
n/a
Meas. Tech.
ChEMBL_1449472 (CHEMBL3373888)
IC50
124±n/a nM
Citation
 Janssen, FJ; Deng, H; Baggelaar, MP; Allarà, M; van der Wel, T; den Dulk, H; Ligresti, A; van Esbroeck, AC; McGuire, R; Di Marzo, V; Overkleeft, HS; van der Stelt, M Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipasea anda/ß-hydrolase domain 6. J Med Chem 57:6610-22 (2014) [PubMed]  Article 
Target
Name:
Diacylglycerol lipase-alpha
Synonyms:
DGL-alpha | DGLA_MOUSE | Dagla | Kiaa0659 | Neural stem cell-derived dendrite regulator | Nsddr | Sn1-specific diacylglycerol lipase alpha
Type:
PROTEIN
Mol. Mass.:
115371.22
Organism:
Mus musculus
Description:
ChEMBL_101098
Residue:
1044
Sequence:
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFALAAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHRGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEDQVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHRNSSVRSKSQSEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSATIEEEEAAGGSEGGGVAPRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDKIRTSTPTGHGASPTKQDDLVISAR
  
Inhibitor
Name:
BDBM50048620
Synonyms:
CHEMBL3319620
Type:
Small organic molecule
Emp. Form.:
C26H27NO6S
Mol. Mass.:
481.561
SMILES:
CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: