Reaction Details Report a problem with these data
Target
Sodium-dependent proline transporter
Ligand
BDBM50052716
Substrate
n/a
Meas. Tech.
ChEMBL_1456629 (CHEMBL3370229)
IC50
700±n/a nM
Citation
 Zipp, GG; Barbosa, J; Green, MA; Terranova, KM; Fink, C; Yu, XC; Nouraldeen, A; Wilson, A; Savelieva, K; Lanthorn, TH; David Kimball, S Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. Bioorg Med Chem Lett 24:3886-90 (2014) [PubMed]  Article 
Target
Name:
Sodium-dependent proline transporter
Synonyms:
PROT | SC6A7_HUMAN | SLC6A7 | Sodium-dependent proline transporter | Solute carrier family 6 member 7
Type:
PROTEIN
Mol. Mass.:
70910.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109456
Residue:
636
Sequence:
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
  
Inhibitor
Name:
BDBM50052716
Synonyms:
CHEMBL3318572
Type:
Small organic molecule
Emp. Form.:
C25H27ClN4O
Mol. Mass.:
434.961
SMILES:
CC(C)(C)C1CN(CCN1C(=O)c1ccc(cc1)-c1cccc(Cl)c1)c1ncccn1
Structure:
Search PDB for entries with ligand similarity: