Reaction Details Report a problem with these data
Target
Deoxyribonuclease-1
Ligand
BDBM50157830
Substrate
n/a
Meas. Tech.
ChEMBL_1517027 (CHEMBL3619486)
IC50
>100000±n/a nM
Citation
 Chapman, TM; Wallace, C; Gillen, KJ; Bakrania, P; Khurana, P; Coombs, PJ; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4104-8 (2015) [PubMed]  Article 
Target
Name:
Deoxyribonuclease-1
Synonyms:
DNAS1_HUMAN | DNASE1 | DNL1 | DNL1 | DNase I | DRNI | Deoxyribonuclease I | Deoxyribonuclease-1 | INN=Dornase alfa
Type:
PROTEIN
Mol. Mass.:
31422.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109543
Residue:
282
Sequence:
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
  
Inhibitor
Name:
BDBM50157830
Synonyms:
3-Hydroxy-7-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dione | CHEMBL361011
Type:
Small organic molecule
Emp. Form.:
C12H8N2O3S
Mol. Mass.:
260.269
SMILES:
On1c(=O)[nH]c2c(csc2c1=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: