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Target
G-protein coupled bile acid receptor 1
Ligand
BDBM50161837
Substrate
n/a
Meas. Tech.
ChEMBL_1572016 (CHEMBL3796544)
EC50
38±n/a nM
Citation
 Agarwal, S; Patil, A; Aware, U; Deshmukh, P; Darji, B; Sasane, S; Sairam, KV; Priyadarsiny, P; Giri, P; Patel, H; Giri, S; Jain, M; Desai, RC Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist. ACS Med Chem Lett 7:51-5 (2016) [PubMed]  Article 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM50161837
Synonyms:
CHEMBL3794293
Type:
Small organic molecule
Emp. Form.:
C28H29FN2O3S
Mol. Mass.:
492.605
SMILES:
COc1ccc(cc1OC)C(C)(C)c1cnc(SCCOc2ccccc2)n1-c1ccc(F)cc1
Structure:
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