Reaction Details
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50221499
Substrate
n/a
Meas. Tech.
ChEMBL_208265 (CHEMBL813225)
IC50
59.9±n/a nM
Citation
Hotoda, H; Daigo, M; Furukawa, M; Murayama, K; Hasegawa, CA; Kaneko, M; Muramatsu, Y; Ishii, MM; Miyakoshi, S; Takatsu, T; Inukai, M; Kakuta, M; Abe, T; Fukuoka, T; Utsui, Y; Ohya, S Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds. Bioorg Med Chem Lett 13:2833-6 (2003) [PubMed] Article More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_ECOLI | Phospho-N-acetylmuramoyl-pentapeptide-transferase/UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | mraY | murX
Type:
PROTEIN
Mol. Mass.:
39889.38
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_1454117
Residue:
360
Sequence:
MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
Inhibitor
Name:
BDBM50221499
Synonyms:
CHEMBL318555
Type:
Small organic molecule
Emp. Form.:
C30H45N5O12
Mol. Mass.:
667.7046
SMILES:
[H][C@@]1(O[C@H]([C@H](OCCCCCC)[C@@H]1OC)n1ccc(=O)[nH]c1=O)[C@@H](O[C@H]1OC(=C[C@H](O)[C@@H]1O)C(=O)N[C@H]1CCC[C@@H](C)NC1=O)C(N)=O |c:29|
Structure:
