Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM278737
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
pH
7.2±n/a
IC50
15.0±n/a nM
Comments
extracted
Citation
 Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolopyridazine inhibitors of IRAK4 activity US Patent  US10040798 Publication Date 8/7/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM278737
Synonyms:
N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oct- 2-yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate | US10040798, Example 34
Type:
Small organic molecule
Emp. Form.:
C20H21ClF3N7O3
Mol. Mass.:
499.874
SMILES:
OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(Cl)n1 |r|
Structure:
Search PDB for entries with ligand similarity: