Reaction Details Report a problem with these data
Target
Bone morphogenetic protein receptor type-1B
Ligand
BDBM280366
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases
IC50
>10000±n/a nM
Citation
 Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent  US10030004 Publication Date 7/24/2018 
Target
Name:
Bone morphogenetic protein receptor type-1B
Synonyms:
ALK-6:ALK6 | Activin receptor-like kinase 6 | Acvrlk6 | BMP type-1B receptor | BMPR-1B | BMR1B_MOUSE | Bmpr1b | SKR6 | Serine/threonine-protein kinase receptor R6
Type:
Enzyme
Mol. Mass.:
56951.97
Organism:
Mus musculus (Mouse)
Description:
P36898
Residue:
502
Sequence:
MLLRSSGKLNVGTKKEDGESTAPTPRPKILRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGMPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTALRVKKTLAKMSESQDIKL
  
Inhibitor
Name:
BDBM280366
Synonyms:
2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyridin-4-amine | US10030004, Compound 32 | US10501436, Compound 32 | US11053216, Compound 32 | US11702401, Compound 32
Type:
Small organic molecule
Emp. Form.:
C21H16ClFN4
Mol. Mass.:
378.83
SMILES:
Fc1ccc(Cl)cc1-c1cc(Nc2ccnc3[nH]ccc23)c(cn1)C1CC1
Structure:
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