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Found 2411 with Last Name = 'chakravarty' and Initial = 's'
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50036833(CHEMBL2371961 | D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Ti...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50036833(CHEMBL2371961 | D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Ti...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity towards bradykinin receptor B2 using [3H]-bradykininMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052513(8-Methyl-3-(2-oxo-propyl)-1-phenethyl-1,3,8-triaza...)
Affinity DataKi:  0.150nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50045210(CHEMBL2370040 | D-Arg-Arg-Pro-Hyp-Calpha-methylGly...)
Affinity DataKi:  0.540nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052512(1-Cyclohexyl-8-methyl-3-(2-oxo-propyl)-1,3,8-triaz...)
Affinity DataKi:  0.570nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50045215(CHEMBL2370010 | D-Arg-Arg-cyclo[Cys-Pro-Gly-Cys]-S...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285024(3-[3-(4-Carbamimidoyl-benzoylamino)-propionylamino...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]-SKF-107260 from alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285023((R)-3-[3-(4-Carbamimidoyl-benzoylamino)-propionyla...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-SKF-107260 from alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052511(8-Methyl-3-(2-oxo-propyl)-1-p-tolyl-1,3,8-triaza-s...)
Affinity DataKi:  6.30nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052509(1-Cyclohexylmethyl-8-methyl-3-(2-oxo-propyl)-1,3,8...)
Affinity DataKi:  6.80nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052514(8-Methyl-3-(2-oxo-propyl)-1-phenyl-1,3,8-triaza-sp...)
Affinity DataKi:  7.70nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50045211(CHEMBL2370011 | D-Arg-Arg-cyclo[Cys-Pro-Gly-Phe-Cy...)
Affinity DataKi:  15nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50045213(CHEMBL2370042 | D-Arg-Arg-Pro-Hyp-N-methylGly-Phe-...)
Affinity DataKi:  26nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052510(8-Methyl-3-(2-oxo-propyl)-1-propyl-1,3,8-triaza-sp...)
Affinity DataKi:  27nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50045208(CHEMBL2370028 | D-Arg-Arg-Pro-Hyp-Calpha-methylGly...)
Affinity DataKi:  31nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50045212(CHEMBL2370041 | D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Ti...)
Affinity DataKi:  82nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50036834(CHEMBL262639 | D-Arg-Arg-(12-aminododecanoyl)-Ser-...)
Affinity DataKi:  360nMAssay Description:Binding affinity towards bradykinin receptor B2 using [3H]-bradykininMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50045209(CHEMBL2370038 | D-Arg-Arg-Pro-Hyp-N-methylGly-N-me...)
Affinity DataKi:  1.69E+3nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50045214(CHEMBL2370035 | D-Arg-Arg-Pro-Hyp-Gly-N-methylPhe-...)
Affinity DataKi:  3.03E+3nMAssay Description:Binding affinity against [3H]-bradykinin binding to bradykinin receptor B2 in guinea pig ileal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525710(US11174252, Compound 4)
Affinity DataIC50:  0.100nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636722((R)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50:  0.200nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525562(US11174252, Compound 1)
Affinity DataIC50:  0.200nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525562(US11174252, Compound 1)
Affinity DataIC50:  0.200nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636718(US11826430, Compound 1.2a)
Affinity DataIC50:  0.300nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525763(US11174252, Compound 450)
Affinity DataIC50:  0.300nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636723((S)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50:  0.400nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525771(US11174252, Compound 458)
Affinity DataIC50:  0.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240227(CHEMBL4084391)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity was determined against HSV-1 Ribonucleoside diphosphate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525786(US11174252, Compound 474)
Affinity DataIC50:  0.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240209(CHEMBL4068526)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525763(US11174252, Compound 450)
Affinity DataIC50:  0.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50323728(2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazo...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using biotinylated PIP2 as substrate in presence of streptavidin-APC by FRET assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525754(US11174252, Compound 441)
Affinity DataIC50:  0.600nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetWee1-like protein kinase(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549228(US11299493, Compound 1.144 | US11299493, S-47)
Affinity DataIC50:  0.600nMAssay Description:IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed in 1×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetWee1-like protein kinase(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549213(US11299493, Compound 1.131 | US11299493, S-33)
Affinity DataIC50:  0.600nMAssay Description:IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed in 1×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636724(N-(2-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-di...)
Affinity DataIC50:  0.600nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636722((R)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50:  0.600nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636721(4-(3-(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-...)
Affinity DataIC50:  0.600nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525710(US11174252, Compound 4)
Affinity DataIC50:  0.700nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50323728(2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazo...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PI3Kdelta (unknown origin) in presence of [gamma-32P]ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525717(US11174252, Compound 12)
Affinity DataIC50:  0.700nMAssay Description:CDK5 (p25): IC50 values of compounds against CDK5 (p25) were determined by Z′-LYTE™. These screening assays were performed at Invitrogen L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240213(CHEMBL4085366)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525762(US11174252, Compound 449)
Affinity DataIC50:  0.900nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Integral Biosciences

Curated by ChEMBL
LigandPNGBDBM50240224(CHEMBL4095856)
Affinity DataIC50:  1nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636726(US11826430, Compound 1.8 | imidazolidin-1-yl)ethyl...)
Affinity DataIC50:  1nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636725(N-(2-(5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)p...)
Affinity DataIC50:  1nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636718(US11826430, Compound 1.2a)
Affinity DataIC50:  1nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM594883(US11584756, Compound 2 | US11584756, Example S-2)
Affinity DataIC50:  1nMAssay Description:The bromodomain binding assays were performed by Reaction Biology Corp., Malvern, Pa., USA (www.reactionbiology.com). The BET binding assays were con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetWee1-like protein kinase(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549240(US11299493, Compound 1.156 | US11299493, S-59)
Affinity DataIC50:  1nMAssay Description:IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed in 1×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetWee1-like protein kinase(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM549236(US11299493, Compound 1.152 | US11299493, S-55)
Affinity DataIC50: <1nMAssay Description:IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed in 1×...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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