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Target
Cyclin-dependent kinase 4
Ligand
BDBM107750
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7.5±0
IC50
27±n/a nM
Citation
 Howard, S; Mortenson, PN; Hiscock, SD; Woolford, AJ; Woodhead, AJ; Chessari, G; O'Reilly, M; Congreve, MS; Dagostin, C; Cho, YS; Yang, F; Chen, CH; Brain, CT; Lagu, B; Wang, Y; Kim, S; Giraldes, J; Luzzio, MJ; Perez, LB Imidazole derivatives and their use as modulators of cyclin dependent kinases US Patent  US8598217 Publication Date 12/3/2013 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
Cyclin-dependent kinase 4 (CDK4)
Type:
Enzyme
Mol. Mass.:
21063.86
Organism:
Oryctolagus cuniculus (Rabbit)
Description:
Q0GMK6
Residue:
189
Sequence:
HFVALKSVRVPNGGGAGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMCQFLRGLDFLHANCIVHRDLKPENILVTSSGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSAGCIFAEMFRRKPLFCGNS
  
Inhibitor
Name:
BDBM107750
Synonyms:
US8598217, 86
Type:
Small organic molecule
Emp. Form.:
C28H26N6O
Mol. Mass.:
462.5456
SMILES:
CN1CCN(Cc2ccc3nc([nH]c3c2)C(=O)c2ccnc(c2)-c2cncc3ccccc23)CC1
Structure:
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