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Target
Urea transporter 1
Ligand
BDBM115195
Substrate
n/a
Meas. Tech.
UT-B Inhibition Assay
IC50
>5.0e+4±n/a nM
Citation
 Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol 20:1235-44 (2013) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B)
Type:
Protein
Mol. Mass.:
42037.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
384
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
  
Inhibitor
Name:
BDBM115195
Synonyms:
1‐N‐[bis(methylsulfanyl)‐1,3,5‐triazin‐2‐yl]‐4‐N‐ phenylbenzene‐1,4‐diamine | UT-A1 inhibitor C2
Type:
Small organic molecule
Emp. Form.:
C17H17N5S2
Mol. Mass.:
355.48
SMILES:
CSc1nc(Nc2ccc(Nc3ccccc3)cc2)nc(SC)n1
Structure:
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