Reaction Details
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Tyrosine-protein phosphatase non-receptor type 4
Ligand
BDBM124261
Substrate
n/a
Meas. Tech.
PTP inhibition assay
pH
7.2±n/a
IC50
6.0e+2± 9e+3 nM
Comments
extracted
Citation
Han, H; Lu, L; Wang, Q; Zhu, M; Yuan, C; Xing, S; Fu, X Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B. Dalton Trans 41:11116-24 (2012) [PubMed] Article More Info.:
Target
Name:
Tyrosine-protein phosphatase non-receptor type 4
Synonyms:
Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2) | PTN4_HUMAN | PTPN4 | Protein-tyrosine phosphatase MEG1 | Tyrosine-protein phosphatase non-receptor type 4 (PTP-MEG1)
Type:
Protein
Mol. Mass.:
105923.44
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
926
Sequence:
MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSTNK
Inhibitor
Name:
BDBM124261
Synonyms:
2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua-oxovanadium(IV) (2)
Type:
Small organic molecule
Emp. Form.:
C14H12N2O8V
Mol. Mass.:
387.1941
SMILES:
[OH2+][V]12([OH2+])(=O)OC(=O)c3ccccc3[N]1=Cc1cc(ccc1O2)[N+]([O-])=O |c:15|
Structure:
