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Found 1516 with Last Name = 'fu' and Initial = 'x'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160893(8-Methyl-3-(4-thiophen-3-yl-phenyl)-8-aza-bicyclo[...)
Affinity DataKi:  0.0170nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160892(3-(4-Thiophen-2-yl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175644(CHEMBL200044 | methyl 3-(4-(furan-2-yl)phenyl)-8-a...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160894(8-Methyl-3-(4-thiophen-2-yl-phenyl)-8-aza-bicyclo[...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160898(3-(4-Thiophen-3-yl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113332(3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-2-t...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor in humansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175634(CHEMBL200698 | methyl 3-(4-(furan-3-yl)phenyl)-8-m...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50095027((2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-eth...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor in humansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160895(3-[4-(5-Bromo-thiophen-2-yl)-phenyl]-8-methyl-8-az...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175646(3-(3',5'-difluoro-biphenyl-4-yl)-8-methyl-8-aza-bi...)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50010195((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175640(3-(3'-fluoro-biphenyl-4-yl)-8-methyl-8-aza-bicyclo...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113325((4-Fluoro-phenyl)-{1-[2-(3-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  0.510nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160889(3-[4-(5-Chloro-thiophen-2-yl)-phenyl]-8-methyl-8-a...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113330((4-Fluoro-phenyl)-{1-[2-(2-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  0.910nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50010195((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]GBR-12935 from dopamine transporter of rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175648(CHEMBL199704 | methyl 3-(4-(furan-2-yl)phenyl)-8-m...)
Affinity DataKi:  1.13nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113333((4-Nitro-phenyl)-(1-phenethyl-piperidin-4-yl)-meth...)
Affinity DataKi:  1.15nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113331((4-Fluoro-phenyl)-{1-[2-(2-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity (Ki) at Dopamine receptor D2 using rat caudate cells with nemonapride (0.075 nM) as a radioligand and 10 M haloperidol as a blank ag...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50063581(CHEMBL3398612)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to coagulation factor 11a (unknown origin) assessed as inhibition constant using (p-Glu-Pro-Arg-pNa,HCl) as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175642(CHEMBL199743 | methyl 3-(4-(5-methoxypyridin-3-yl)...)
Affinity DataKi:  1.56nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113329((4-Fluoro-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-p...)
Affinity DataKi:  1.63nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175647(CHEMBL382943 | methyl 8-methyl-3-(4-(thiazol-2-yl)...)
Affinity DataKi:  1.67nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113331((4-Fluoro-phenyl)-{1-[2-(2-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  1.95nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Yale University

Curated by ChEMBL
LigandPNGBDBM50010195((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175643(CHEMBL199634 | methyl 8-methyl-3-(4-(pyridin-3-yl)...)
Affinity DataKi:  3.51nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113324((4-Fluoro-phenyl)-{1-[2-(4-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  3.62nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113331((4-Fluoro-phenyl)-{1-[2-(2-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  3.68nMAssay Description:Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175644(CHEMBL200044 | methyl 3-(4-(furan-2-yl)phenyl)-8-a...)
Affinity DataKi:  3.76nMAssay Description:Displacement of [3H]GBR-12935 from DAT in rat rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175639(CHEMBL199850 | methyl 3-(4-(5-methoxypyridin-3-yl)...)
Affinity DataKi:  3.91nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160897(3-[4-(4-Bromo-thiophen-3-yl)-phenyl]-8-methyl-8-az...)
Affinity DataKi:  4.02nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160889(3-[4-(5-Chloro-thiophen-2-yl)-phenyl]-8-methyl-8-a...)
Affinity DataKi:  4.42nMAssay Description:Displacement of [3H]GBR-12935 from dopamine transporter of rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160890(3-[4-(5-Iodo-thiophen-2-yl)-phenyl]-8-methyl-8-aza...)
Affinity DataKi:  4.56nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175636(CHEMBL381418 | methyl 3-(4-(thiazol-2-yl)phenyl)-8...)
Affinity DataKi:  5.15nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160898(3-(4-Thiophen-3-yl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]GBR-12935 from dopamine transporter of rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160895(3-[4-(5-Bromo-thiophen-2-yl)-phenyl]-8-methyl-8-az...)
Affinity DataKi:  6.43nMAssay Description:Displacement of [3H]GBR-12935 from dopamine transporter of rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175648(CHEMBL199704 | methyl 3-(4-(furan-2-yl)phenyl)-8-m...)
Affinity DataKi:  7.14nMAssay Description:Displacement of [3H]GBR-12935 from DAT in rat rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113324((4-Fluoro-phenyl)-{1-[2-(4-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  7.32nMAssay Description:Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113325((4-Fluoro-phenyl)-{1-[2-(3-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  8.76nMAssay Description:Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50572517(CHEMBL4865339)
Affinity DataKi:  9nMAssay Description:Binding affinity to coagulation factor 11a (unknown origin) assessed as inhibition constant using (p-Glu-Pro-Arg-pNa,HCl) as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113339((4-Nitro-phenyl)-(1-phenethyl-piperidin-4-yl)-meth...)
Affinity DataKi:  9.34nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113326((4-Fluoro-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-p...)
Affinity DataKi:  9.54nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175637(CHEMBL383572 | methyl 8-methyl-3-(4-(pyrazin-2-yl)...)
Affinity DataKi:  11.3nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160893(8-Methyl-3-(4-thiophen-3-yl-phenyl)-8-aza-bicyclo[...)
Affinity DataKi:  12.1nMAssay Description:Displacement of [3H]GBR-12935 from dopamine transporter of rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50160892(3-(4-Thiophen-2-yl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Affinity DataKi:  12.2nMAssay Description:Displacement of [3H]GBR-12935 from dopamine transporter of rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Yale University

Curated by ChEMBL
LigandPNGBDBM50175644(CHEMBL200044 | methyl 3-(4-(furan-2-yl)phenyl)-8-a...)
Affinity DataKi:  12.7nMAssay Description:Displacement of [3H]nisoxetine from NET in rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113328((4-Fluoro-phenyl)-[1-(3-iodo-benzyl)-piperidin-4-y...)
Affinity DataKi:  12.7nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113340((4-Fluoro-phenyl)-{1-[2-(3-iodo-phenyl)-ethyl]-pip...)
Affinity DataKi:  13.1nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM50175634(CHEMBL200698 | methyl 3-(4-(furan-3-yl)phenyl)-8-m...)
Affinity DataKi:  14.2nMAssay Description:Displacement of [3H]GBR-12935 from DAT in rat rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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