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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM143354
Substrate
n/a
Meas. Tech.
FAAH Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
12±n/a nM
Comments
extracted
Citation
 Kharul, R; Bhuniya, D; Mookhtiar, KA; Singh, U; Hazare, A; Patil, S; Datrange, L; Thakkar, M Amide compounds, compositions and applications thereof US Patent  US9682953 Publication Date 6/20/2017 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM143354
Synonyms:
US9682953, 11.1
Type:
Small organic molecule
Emp. Form.:
C26H22F3N7O2
Mol. Mass.:
521.4938
SMILES:
FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-c3nnn[nH]3)c2)nc1 |(-14.34,4.74,;-13.01,5.51,;-13.01,7.05,;-13.01,3.97,;-11.68,4.74,;-10.34,5.51,;-9.01,4.74,;-9.01,3.2,;-7.68,2.43,;-6.34,3.2,;-6.34,4.74,;-5.01,5.51,;-3.67,4.74,;-3.67,3.2,;-2.34,2.43,;-1.01,3.2,;.33,2.43,;1.66,3.2,;1.66,4.74,;.33,5.51,;-1.01,4.74,;2.99,5.51,;4.33,4.74,;4.33,3.2,;5.66,5.51,;6.99,4.74,;8.38,5.48,;8.33,7.05,;6.99,7.82,;5.66,7.05,;9.66,7.82,;11.07,7.19,;12.1,8.34,;11.33,9.67,;9.82,9.35,;-5.01,2.43,;-10.34,2.43,;-11.68,3.2,)|
Structure:
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