Reaction Details Report a problem with these data
Target
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3)
Ligand
BDBM285531
Substrate
n/a
Meas. Tech.
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays
IC50
>27100±n/a nM
Citation
 Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent  US10077269 Publication Date 9/18/2018 
Target
Name:
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3)
Synonyms:
DPDE3 | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D | NP_000914.2 | PDE4C1 | PDE4D | PDE4D3 | PDE4D_HUMAN | PDE4E3 | Q08499-2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3)
Type:
n/a
Mol. Mass.:
76431.39
Organism:
Homo sapiens (Human)
Description:
Q08499-2
Residue:
673
Sequence:
MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM285531
Synonyms:
N-Cyclopropyl-3-(2-methoxypyrimidin-5-yl)imidazo[1,2-b]pyridazine-2-carboxamide (4) | US10077269, Example 4 | US10669279, Example 4
Type:
Small organic molecule
Emp. Form.:
C15H14N6O2
Mol. Mass.:
310.3107
SMILES:
COc1ncc(cn1)-c1c(nc2cccnn12)C(=O)NC1CC1
Structure:
Search PDB for entries with ligand similarity: