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Target
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3)
Ligand
BDBM285536
Substrate
n/a
Meas. Tech.
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays
IC50
1490±n/a nM
Citation
 Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent  US10077269 Publication Date 9/18/2018 
Target
Name:
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3)
Synonyms:
DPDE3 | Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D | NP_000914.2 | PDE4C1 | PDE4D | PDE4D3 | PDE4D_HUMAN | PDE4E3 | Q08499-2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3)
Type:
n/a
Mol. Mass.:
76431.39
Organism:
Homo sapiens (Human)
Description:
Q08499-2
Residue:
673
Sequence:
MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM285536
Synonyms:
3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimidazo[1,2-b]pyridazine-2-carboxamide (9) | US10077269, Example 9 | US10669279, Example 9 | US9598421, Example 9
Type:
Small organic molecule
Emp. Form.:
C16H11ClF2N4O
Mol. Mass.:
348.735
SMILES:
Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl |(8.76,-6.6,;7.27,-7,;6.88,-8.49,;5.39,-8.89,;4.99,-10.38,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.44,-11.62,;8.21,-10.29,;8.21,-12.96,;9.75,-12.96,;11.08,-13.73,;11.08,-12.19,;4.3,-7.8,;2.81,-8.2,;4.7,-6.31,;6.19,-5.91,;6.58,-4.43,)|
Structure:
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