Reaction Details
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Thymidine phosphorylase
Ligand
BDBM50019168
Substrate
n/a
Meas. Tech.
Thymidine Phosphorylase Inhibition Assay
pH
7±n/a
IC50
2.946e+5± 2.9e+3 nM
Comments
extracted
Citation
Javaid, S; Saad, SM; Perveen, S; Khan, KM; Choudhary, MI 2-Arylquinazolin-4(3H)-ones: A novel class of thymidine phosphorylase inhibitors. Bioorg Chem 63:142-51 (2015) [PubMed] Article More Info.:
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECOSM | Thymidine phosphorylase (TP) | deoA
Type:
Protein
Mol. Mass.:
47171.52
Organism:
Escherichia coli (Enterobacteria)
Description:
B1LEI7
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAAIKLADKAPESTPTVYRRISE
Inhibitor
Name:
BDBM50019168
Synonyms:
2-(3'-Hydroxyphenyl)quinazolin-4(3H)-one (3) | CHEMBL3289110
Type:
Small organic molecule
Emp. Form.:
C14H10N2O2
Mol. Mass.:
238.2414
SMILES:
Oc1cccc(c1)-c1nc2ccccc2c(=O)[nH]1
Structure:
