Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM182741
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assay
pH
7.4±n/a
IC50
7.8±n/a nM
Comments
extracted
Citation
 van Duzer, JH; Mazitschek, R Selective HDAC1 and HDAC2 inhibitors US Patent  US9145412 Publication Date 9/29/2015 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM182741
Synonyms:
US9145412, Table 1, Compound 7
Type:
Small organic molecule
Emp. Form.:
C29H29N5O
Mol. Mass.:
463.5735
SMILES:
Nc1ccc(cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: