Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM182760
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assay
pH
7.4±n/a
IC50
36±n/a nM
Comments
extracted
Citation
 van Duzer, JH; Mazitschek, R Selective HDAC1 and HDAC2 inhibitors US Patent  US9145412 Publication Date 9/29/2015 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM182760
Synonyms:
US9145412, Table 1, Compound 47
Type:
Small organic molecule
Emp. Form.:
C27H29N5O2S
Mol. Mass.:
487.616
SMILES:
Nc1ccc(cc1NC(=O)c1cnc2n(CCN3CCOCC3)c(cc2c1)C1CC1)-c1cccs1
Structure:
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