Reaction Details Report a problem with these data
Target
P2X purinoceptor 3
Ligand
BDBM183110
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
420±n/a nM
Comments
extracted
Citation
 Kai, H; Kameyama, T; Hasegawa, T; Oohara, M; Tada, Y; Endoh, T Triazine derivative and pharmaceutical composition comprising the same US Patent  US9150546 Publication Date 10/6/2015 
Target
Name:
P2X purinoceptor 3
Synonyms:
ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa
Type:
Protein
Mol. Mass.:
44292.02
Organism:
Homo sapiens (Human)
Description:
P56373
Residue:
397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
  
Inhibitor
Name:
BDBM183110
Synonyms:
US9150546, I-248 | US9688643, I-248 | US9718790, I-0248
Type:
Small organic molecule
Emp. Form.:
C21H21ClN4O4
Mol. Mass.:
428.869
SMILES:
COC(=O)c1ccc(Nc2nc(=O)n(C(C)C)c(=O)n2Cc2ccc(Cl)cc2)cc1
Structure:
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