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Target
BRISC and BRCA1-A complex member 1/BRISC and BRCA1-A complex member 2/BRISC complex subunit Abraxas 2/Lys-63-specific deubiquitinase BRCC36
Ligand
BDBM224012
Substrate
n/a
Meas. Tech.
In Vitro BRCC36 Activity Assay
IC50
2.3e+3±n/a nM
Citation
 Li, J; Yakushi, T; Parlati, F; Mackinnon, AL; Perez, C; Ma, Y; Carter, KP; Colayco, S; Magnuson, G; Brown, B; Nguyen, K; Vasile, S; Suyama, E; Smith, LH; Sergienko, E; Pinkerton, AB; Chung, TDY; Palmer, AE; Pass, I; Hess, S; Cohen, SM; Deshaies, RJ Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol 13:486-493 (2017) [PubMed]  Article 
Target
Name:
BRISC and BRCA1-A complex member 1/BRISC and BRCA1-A complex member 2/BRISC complex subunit Abraxas 2/Lys-63-specific deubiquitinase BRCC36
Synonyms:
BRISC complex
Type:
Protein
Mol. Mass.:
n/a
Description:
Human BRISC complex (BRCC36/KIAA0157/BRCC45/MERIT40)
Components:
This complex has 4 components.
Component 1
Name:
Lys-63-specific deubiquitinase BRCC36
Synonyms:
BRCC3 | BRCC36 | BRCC3_HUMAN | BRISC complex subunit BRCC36 (BRCC36) | C6.1A | CXorf53
Type:
Protein
Mol. Mass.:
36065.48
Organism:
Homo sapiens (Human)
Description:
P46736
Residue:
316
Sequence:
MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKSSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEELMQELSSLE
  
Component 2
Name:
BRISC complex subunit Abraxas 2
Synonyms:
ABRAXAS2 | ABRO1 | ABRX2_HUMAN | BRISC complex subunit Abro1 (KIAA0157) | FAM175B | KIAA0157
Type:
Protein
Mol. Mass.:
46897.76
Organism:
Homo sapiens (Human)
Description:
Q15018
Residue:
415
Sequence:
MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNEKEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDFHPNNQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSGEDSDDSDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
  
Component 3
Name:
BRISC and BRCA1-A complex member 2
Synonyms:
BABA2_HUMAN | BABAM2 | BRCC45 | BRE | BRISC complex subunit BRCC45 (BRCC45)
Type:
Protein
Mol. Mass.:
43546.64
Organism:
Homo sapiens (Human)
Description:
Q9NXR7
Residue:
383
Sequence:
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
  
Component 4
Name:
BRISC and BRCA1-A complex member 1
Synonyms:
BABA1_HUMAN | BABAM1 | BRISC complex subunit MERIT40 (MERIT40) | C19orf62 | MERIT40 | NBA1
Type:
Protein
Mol. Mass.:
36535.96
Organism:
Homo sapiens (Human)
Description:
Q9NWV8
Residue:
329
Sequence:
MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLAHPLQRPCQSHASYSLLEEEDEAIEVEATV
  
Inhibitor
Name:
BDBM224012
Synonyms:
Capzimin | US10005735, Compound 12
Type:
Small organic molecule
Emp. Form.:
C15H13N3OS2
Mol. Mass.:
315.413
SMILES:
Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1
Structure:
Search PDB for entries with ligand similarity: