Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM239897
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
530±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239897
Synonyms:
US9403767, 60 | US9403767, 61
Type:
Small organic molecule
Emp. Form.:
C21H34N2
Mol. Mass.:
314.5081
SMILES:
CNC1(CCC(CC2CCCC2)(CC1)N(C)C)c1ccccc1 |(8.28,-6.8,;8.5,-5.28,;7.29,-4.33,;6.76,-2.88,;5.24,-2.62,;4.25,-3.8,;2.92,-4.57,;2.92,-6.11,;4.16,-7.01,;3.69,-8.48,;2.15,-8.48,;1.67,-7.01,;4.78,-5.24,;6.3,-5.51,;3.26,-2.62,;3.79,-1.17,;1.75,-2.88,;8.75,-3.86,;9.07,-2.35,;10.53,-1.87,;11.68,-2.9,;11.36,-4.41,;9.89,-4.89,)|
Structure:
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